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Your metabolism adjusts to match your current body composition, just as it would after any weight loss method

393 As a result, GLP-1RAs could mitigate the detrimental effects of hyperlipidemia-induced skeletal defects, leading to an improved prognosis in individuals with OA

Somatostatin, the hormone that normally inhibits growth hormone release, continues functioning properly, maintaining physiological balance

Moreover, Wang et al

Orforglipron: Phase 3 trial results are expected in 2025

If you are taking a GLP-1, it is smart to coordinate with your prescribing clinician, especially if you have diabetes, a history of low blood sugar, digestive side effects, or other medical concerns