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Semaglutide (also injected weekly) was associated with an average weight loss of around 11% after 24 to 68 weeks, with evidence suggesting the effect can persist for up to two years, based on 18 randomized controlled trials (27 949 participants)

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By contrast, the control group saw an average 2.9% weight loss compared to their baseline weight at the two year point

Long-term safety, potential adverse effects, and inconsistent clinical outcomes remain challenges that must be addressed

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(2024, August 21)