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2012;7(6):e38901

But, in January 2018, the FDA stepped in

In the zona glomerulosa of the adrenal cortex, activation of AT 1 R triggers the release of mineralocorticoids [149], which elevate blood pressure primarily via stimulation of sodium reabsorption and expansion of plasma volume, and secondarily via non-genomic mineralocorticoid receptor (MR)-mediated actions [155]

Rotate injection sites (abdomen, thighs, upper arms) to reduce local irritation

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