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Curcumin improves glucose tolerance via stimulation of glucagon-like peptide-1 secretion

Clinical observations show 25% body fat reduction over 1216 weeks in patients who maintain a modest caloric deficit (300500 kcal/day) and resistance train 34 times weekly

This article was led by Suhas Gondi with an assist from Aaron S

The pivotal Phase 2 trial a 48-week study published in The New England Journal of Medicine in 2023 produced these results in adults with obesity (and no diabetes), at the highest dose of 12 mg weekly: Average weight loss of around 24% from baseline A clear dose-response, with even the 4 mg dose producing roughly 17% weight loss Continued weight loss right up to the 48-week endpoint, with no plateau in sight For context, similar Phase 2 data for Wegovy showed around 15% weight loss at 68 weeks

In the blood of ME/CFS patients, there is an abnormally high level of FGF-21 (Fibroblast Growth Factor-21), which is not only a growth factor but also a hormone (184)

On November 1, Jupiter was at a very close distance to the Earth called perigee