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Acute elevation of FFA in normal subjects diminishes GH secretion, while lowering of FFA in obese subjects increases spontaneous GH secretion, possibly by a direct effect on the somatotrophs

210 Moreover, PGC1 KO mice demonstrated decreased activity during the dark cycle and less response to physiological stresses, like adrenergic stimulation in BAT (brown adipose tissue), cold exposure in BAT, and hepatic steatosis

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doi: 10.1016/j.jconrel.2006.08.013, 203