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(6) Increased bone marrow adipose tissue accumulation and altered mesenchymal stem cell differentiation contribute to reduced osteoblast activity, increased osteoclastic resorption, and an overall decline in bone strength, leading to a greater fracture risk despite higher bone mineral density measurements
Unimolecular polypharmacy for treatment of diabetes and obesity
Notably, these effects occurred at relatively low doses, were well-tolerated, and were accompanied by weight loss
Baseline bone density testing is not routinely required for all patients but may be appropriate for those at higher risk, including postmenopausal women, older adults, individuals with prior fractures, or those with documented osteopenia or osteoporosis
At-home blood test option Easy at home option to monitor core metrics during research cycles
