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Compared with sham rats, LOsG-treated rats showed a 4-fold increase in ROS production in islet cells ( P 0.05, Fig

Upstream kinases that determine clock periodicity also influence liver fat accumulation: disruption of casein kinase 1/ key regulators of PER protein stabilityabolishes rhythmic lipid metabolic oscillations and increases vulnerability to high-fat-dietinduced steatosis (45, 46)

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