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This creates a self-reinforcing pro-inflammatory microenvironment that further impairs follicular development and oocyte developmental competence, linking cellular aging at the molecular level to clinically observable reproductive decline [185, 205]

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Combined treatment with chondroitin sulfate and glucosamine sulfate shows no superiority over placebo for reduction of joint pain and functional impairment in patients with knee osteoarthritis: a six-month multicenter, randomized, double-blind, placebo-controlled clinical trial