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J Autoimmun 40(7):532539 Flouri I, Markatseli TE, Voulgari PV, Boki KA, Papadopoulos I, Settas L, Zisopoulos D, Skopouli FN, Iliopoulos A, Bertsias GK (2014) Comparative effectiveness and survival of infliximab, adalimumab, and etanercept for rheumatoid arthritis patients in the Hellenic Registry of Biologics: low rates of remission and 5-year drug survival
Importantly, this effect was dose-dependent, as increased Ubx N51A level (with constant Ubx WT level) led to higher exon inclusion for pAbp , Pura and Dnc (Figure 1J, Figure S2H, S2N)
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This adrenal dysfunction can directly promote autoimmunity by further stimulating the production of pro-inflammatory molecules