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However, unlike 1 mM metformin and 10 nM semaglutide, 10 nM tirzepatide also increased the levels of additional apoptotic biomarkers such as C-Caspase-3, C-Caspase-9, and Bim EL (Figure 1B)

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Furthermore, immunohistochemical analysis of the knee joints of mouse indicated positive GLP-1R staining in the tibia and femoral articular cartilage, meniscus, and bone marrow of healthy murine knee articular sections (Fig

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