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Insulin-like growth factor-I stimulates the growth of rat thyroid cells in culture and synergizes the stimulation of DNA synthesis induced by TSH and Graves'-IgG

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Glucagon stimulates energy expenditure in the following ways: (1)activation of BAT via direct glucagon receptor activity and indirect fibroblast growth factor 21 (FGF 21)-dependent pathways with downstream effects of increased oxygen consumption (an indirect measure of heat production)

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