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limit generalizability, suggesting the need for further research

If TSH is above 4.5 and free T4 is below 0.8, and thyroid peroxidase (TPO) antibodies are above 500, thats overt hypothyroidism with Hashimotos thyroiditis 5 7 8

Selected References Coskun T, Urva S, Roell WC, et al

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Mitochondrial dysfunction causes abnormal increases in the neurotransmitter glutamate and, again, puts the brain at risk for developing the above problems