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Under normal conditions, robust antioxidant defense systems - including glutathione peroxidase (GPx), thioredoxin reductase, and superoxide dismutase - neutralize this HO before it can damage thyroid cells

Epigenetic aberrations, especially DNA methylation, histone modifications, chromatin remodeling, and small RNAs, have been described in malignant hematological and solid tumors and can be considered as common features of cancer development and progression (Sharma and Rando, 2017

PMID: 34046850 12

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Gastrointestinal (GI) adverse events, including nausea, vomiting, diarrhea and constipation, were mostly mild or moderate (88% with no or mild events)