doi: 10.1002/ejhf.1536 50 PackerMAnkerSDButlerJFilippatosGPocockSJCarsonPet al
Effective transdermal delivery would require advanced technologies such as: Microneedle arrays : Tiny needles that create microscopic channels in the skin to facilitate drug absorption (these are minimally invasive devices rather than traditional patches) Chemical penetration enhancers : Substances that temporarily increase skin permeability Iontophoresis : Using electrical currents to drive charged molecules through the skin Nanoparticle formulations : Encapsulating drugs in carriers designed to cross skin barriers Several preclinical and early-stage studies have explored these approaches for GLP-1 delivery, with some promising results in laboratory and animal models
Future research will probably include more patients with combined therapy, which will help to elucidate the timing and sequence of how these medications should be combined
2021;2021 doi: 10.1155/2021/7809611
513,514 These signaling pathways suggest that GLP-1 and its receptor agonists may influence the progression of NASH through multiple mechanisms, providing several potential therapeutic targets including: FOXO1, a transcription factor that plays a critical role in regulating glucose and lipid metabolism
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