Moreover, we retrieved other relevant records 56,57,58 : two large ( N = 133,318 and N = 342,608, respectively) cohort studies in people with diabetes across 613 years noted a beneficial association between GLP-1RA prescriptions compared with non-prescription and lower diagnoses of dementia 57,58 , while a small ( N = 154 patients with T2DM) and shorter (~12 months) cross-sectional investigation of GLP-1RAs in addition to metformin, compared with metformin alone, observed better MoCA scores in the former group 56
Gallbladder issues: Semaglutide may increase the risk of gallbladder problems, including gallstones or cholecystitis (inflammation of the gallbladder)
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Of note, people with type 2 diabetes had a lower mean percentage weight loss at the 3-month mark compared with those without type 2 diabetes: 3.9% in those with type 2 diabetes vs 6.3% in those without type 2 diabetes
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The results of these subgroup analyses are presented in Table 4, Table 5, Table 6, and Table 7, respectively, illustrating the stratification based on patient gender, age, indications, and treatment duration
