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Consequently, synthetic biology increasingly focuses on the development of multilayered biocontainment strategies that integrate metabolic dependencies, programmable genetic circuits, and multiple orthogonal triggers

However, given the results reported in previous studies (2,25,31-33) that used moderate/high doses of vitamin B12, it should be possible to demonstrate the non-inferiority of the oral treatment with this power level

Acta Neurobiol Exp 68(2):139146

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