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If estradiol rises, they trim milligrams or add a blocker the same week, not six months later

It activates antioxidants and neutralizes ROS (reactive oxygen species) inside the cells

Extrapolating from B12 supplementation trials of non-vegans to determine the needs of vegans is complicated by the fact that a high percentage of any small dose of B12 is absorbed and omnivores are normally receiving numerous small doses throughout the day