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Although demyelination induced by ICIs should be promptly diagnosed and treated according to the guideline for each specific disease (e.g., MS), prescription of GLP-1RAs might be efficacious for the nirAE as a concomitant therapy with immunosuppressors (corticosteroids, intravenous immune globulin, plasmapheresis, etc ) (Rajendram et al., 2021)

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The hippocampus of ASD mice showed significant downregulation in 7nAChRs in thimerosal-induced autistic behavior, while the treated group showed significant improvement in autistic behavior by upregulation of 7nAChRs in the hippocampus [62]

In contrast, chronic co-exposure to arsenic and chromium causes additive nephrotoxicity in zebrafish through oxidative stress and impaired DNA repair

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