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doi: 10.1016/j.vaccine.2017.06.031 170 PrinsenHde VriesIJMTorensmaRPotsJMMulderSFvan HerpenCMLet al

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Altered lymphocyte apoptosis in patients with SLE could contribute to an overload of nucleosome in circulation that could initiate an autoimmune response that might break tolerance, resulting in the autoimmune phenomena

These changes increase the risk of infertility, subfertility, and chromosomal aberrancies in sperm