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Morrissey, C

Moreover, the current and lifetime prevalence of hepatic illness in bipolar disorder stands at 17 and 21%, respectively (42)

These usually occur during the dose-escalation phase and tend to diminish over time. Patients can improve tolerability by consuming smaller portions and avoiding high-fat or spicy meals. Dosing should start low and be increased gradually based on tolerance and clinical goals. Administration and Storage Considerations Injectable agents such as dulaglutide and semaglutide must be refrigerated before the first use

In a dismutation reaction, SOD converts O 2 - to hydrogen peroxide which is then removed by CAT, GPx, and metallothioneins