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The extended half-life (2030 hours) drives systemic IGF-1 receptor activation across multiple tissue types

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For instance, a study utilizing data from the United Kingdom Clinical Practice Research Datalink (UK CPRD) suggested an increased risk of intestinal obstruction in T2DM patients prescribed GLP-1RAs compared to those prescribed sodium-glucose cotransporter-2 (SGLT2) inhibitors [15]

10.1016/j.nrleng.2018.08.004 27 RiemannD.KroneL

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