A study by the same group in the longitudinal DATATOP cohort (deprenyl and tocopherol antioxidative therapy of Parkinsonism) which included individuals with early PD in a placebo-controlled clinical trial reported increased CSF pS129 and pS129/total -synuclein ratio over 2 years of disease progression (Stewart et al., 2015)
10.1038/s41398-021-01468-7 147 WangJ.ChenR.LiuC.WuX.ZhangY
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In a cohort study, individuals who progressed to Alzheimers showed elevated 3-HAA, higher 3-HAA/anthranilic acid ratio, increased 3-HK, and reduced PA, suggesting these KP changes could serve as early biomarkers of cognitive decline [249]
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The reduced shoot/root Cd concentrations of 33.8/42.2% in Weisuobuzhi and 59.4/66.3% in Dong 17 relative to the Cd alone treatment reflects that GSH can suppress plant Cd uptake (Wang et al