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Perluigi M, Tramutola A, Pagnotta S, Barone E, Butterfield DA

BDNF: The Master Neurotrophin Brain-Derived Neurotrophic Factor (BDNF) is arguably the most important molecule in cognitive neurosciencea master regulator of synaptic plasticity, neuronal survival, and cognitive resilience

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This mechanism is primarily associated with inhibiting Mincle and its associated signaling components Syk and NF-B, which regulate macrophage polarizationspecifically reducing pro-inflammatory M1 phenotypes while enhancing anti-inflammatory M2 populations

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El-Maraghy SA, Nassar NN (2011) Modulatory effects of lipoic acid and selenium against cadmium-induced biochemical alterations in testicular steroidogenesis