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For all identified candidate gene sequences, we predicted protein subcellular localisation regions using DeepLoc-2.0, 40,87 , which uses protein sequences as input for Neural Networks algorithm trained on Uniprot proteins with experimental evidence

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Higher mean age and baseline SBP, greater use of anti-hypertensive medications, longer T2D duration, and reduction in insulin daily dose might have contributed to explain the difference observed in the impact of weight loss on SBP reduction in these trials, although direct GLP-1R- and GIP-R-mediated effects could also be considered [77]