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Mild dehydration can be caused when taking this medication and as already discussed it is important to drink enough fluids (and that is not referring to alcohol or caffeine!) to prevent this from happening

Updated May 6, 2026

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10.1016/j.neurobiolaging.2012.04.009 48 HansenG.JelsingJ.VrangN

The overexpression of PGC-1 adeno-associated virus in the brain region of APP23 model mice was observed to result in increased transcription of growth factors, reduced levels of BACE1, and diminished A-mediated neuroinflammation, which collectively led to reduced -amyloid production and neuronal loss (Katsouri et al., 2016)

While GLP-1 receptors are present in the same set of liver cells in humans, the mechanism will need to be verified through human tissue studies