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Many compounds that looked effective in animals later failed human trials or revealed safety concerns

Dr Anastasiou explains: In experiments in the lab, GLP-1-receptor agonists exerted powerful antioxidant effects which protected retinal cells against the type of damage that can occur in diabetes

While there were no significant differences at baseline, a significant drug main effect was found, indicating that GLP-1 concentrations were lower during cannabis administration sessions (oral, smoked, and vaporized), compared to the placebo condition (Fig

This is ultimately a clinical decision for you and your doctor, but trial and real-world data suggest practical patterns: Wegovy may suit better if cardiovascular disease is a key concern as semaglutide has a proven and licensed cardiovascular risk-reduction indication