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In animal studies, MOTS-c administration has been found to increase exercise capacity and improve metabolic parameters independent of activity levels

However, when there is too much TAT-DAT NT , it may excessively enhance dopaminergic neurotransmission and rather exerts its stimulant effects as observed in SHR rats (Fig

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This depends on several things

It is a reasonable precaution in the absence of evidence either way

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