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In addition to these intracellular inflammatory events, the integrity of the bloodbrain barrier (BBB) plays a decisive role in shaping the neuroinflammatory environment in PD [53]

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Fatigue and dizziness affect a smaller percentage of patients, generally appearing 2 to 5 days into treatment and improving by week 3

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[6] The response or effect, E, is dependent on both the binding of the drug and the drug-bound receptor