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The conformational flexibility of TM11 appears to be linked with substrate recognition, with R471 (responsible for carnitine coordination) located near the midpoint of this helix, between the two segments that bend during the transition between inward-facing and occluded conformations

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Studies indicate potential neuroprotective effects, with research showing the peptide may protect against various neurotoxic insults and support dopaminergic system function

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A randomised phase II study investigating durvalumab in addition to an anthracycline taxane-based neoadjuvant therapy in early triple-negative breast cancer: clinical results and biomarker analysis of GeparNuevo study

This leads to enhanced absorption of glucose by cells