The risk in humans is unclear, but doctors recommend careful monitoring while using the medication if you already have a high risk of this condition
Strategies to Minimize Weight Rebound if You Pause or Stop If you must temporarily pause semaglutide for medical reasons, several evidence-based strategies reduce rebound: maintain high protein intake (which provides natural satiety), prioritize structured meal timing to prevent grazing, increase physical activity to offset the metabolic slowdown, and ensure adequate sleep (poor sleep amplifies hunger hormones)
Harrison SA, Ratziu V, Boursier J, et al
Obesity, cancer risk, and time-restricted eating
Because retatrutide remains investigational, I recommend that patients discuss potential side effects with a qualified medical professional and avoid using products marketed outside legitimate clinical trial settings
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