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The researchers collected information on BMI when the participants were between 50 and 60 years old in 1962

PC1/3 antibody (ab220363) was obtained from Abcam (Cambridge, United Kingdom)

Moreover, KO mice for liver IGF-1 gene developed muscle insulin resistance (it is important to mention that skeletal muscle myocytes express high number of IGF-1R), showing an increase in insulin concentrations and a substantial decrease in the insulin-induced autophosphorylation of the insulin receptor and IRS in skeletal muscle (being normal in liver and white adipose tissue)

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Other conceptualizations view the conditions as overlapping comorbidities [2,3]

Chen, H., Gupta, R., & Lee, M