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Another Phase I trial (NCT04629404) was conducted on early-stage PD patients to assess pharmacokinetics, pharmacodynamics, and safety of LY03003, demonstrating well tolerability and promising pharmacodynamic effects, suggesting its suitability for continuous dopaminergic stimulation 141

For instance, in a study, assessing TAM ability to affect the malignant phenotype of human hepatoma Huh-7 cells, TAMs promoted the migration, invasion, and epithelialmesenchymal transition (EMT) of Huh-7 cells through a mechanism requiring activation of the Gli2/IGF-2/ERK1/2 signaling pathway and the resulting secretion of transforming growth factor beta 1 (TGF-1) (24)