Regular supplementation supports consistent fat metabolism, endurance, and energy production
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Notably, the present narrative review is an extension of a previous review article that covered polyphenols and/or phytoestrogens that included daidzein, equol, genistein, and resveratrol as supplemental therapies for skin aging, which was published in Dermatology and Therapy earlier this year by Lephart (2025) [9]
Consistently feeling sad, empty, and hopeless Markedly diminished interest in pleasurable activities Significant weight loss or weight gain Increased or decreased appetite Insomnia or hypersomnia Fatigue or loss of energy Feeling of worthlessness, feeling excessive, or inappropriate guilt Diminished ability to think or concentrate, or indecisiveness Recurrent thoughts of death and suicidal ideation without a specific plan Psychomotor agitation or retardation These symptoms cause clinically significant distress or impairment in social, occupational, or other important areas of functioning
In addition, PF inhibited the production of the inflammatory stimulating factor IL-12 and increased the expression of IL-10 and TGF-
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