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Two separate double-blind, placebo-controlled randomized trials from Imperial College London published in JAMA Network Open in 2022 (women) and 2023 (men) found that kisspeptin significantly changed brain activity in key sexual processing regions in people with hypoactive sexual desire disorder (HSDD)

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Their effects include glucose-dependent insulin secretion, suppression of glucagon secretion, reduced appetite, delayed gastric emptying, and central satiety signaling