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Retatrutide [1] is a unique triple receptor agonist that activates GLP-1 (glucagon-like peptide-1), GIP (glucose-dependent insulinotropic polypeptide), and glucagon receptors

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Retinopathy, Macular Degeneration, and NAION GLP-1 medications may be linked to certain eye complications, mainly in people with diabetes who already have eye disease and experience rapid improvements in blood sugar

doi: 10.1007/978-3-642-24716-3_9 59 SanoHKaneSSanoEMineaCPAsaraJMLaneWSet al

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A study of patients with T2MD and congestive heart failure found that their levels of ANP were increased, whereas blood pressure was decreased, indicating that the GLP-1R-ANP axis is only active in patients with congestive heart failure (123)