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In a phase 2, randomized, double-blind, placebo-controlled trial (NCT05669599) of adults with obesity (with and without type 2 diabetes), once-monthly MariTide produced dose-dependent reductions in body weight of up to 16% at 52 weeks, compared with approximately 2% to 3% with placebo

Furthermore, MOTS-c lowered SASP-related genes such as Il1b and Cxcl10 suggesting a cell-autonomous regulation by MOTS-c in pancreatic islet cells (Fig

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[4] Ultimately, the choice of GLP-1 agonist should be a collaborative decision between the patient and their healthcare provider, taking into account individual factors, treatment goals, and potential risks and benefits

Data on GLP-1 utilization were retrieved from electronic medical records from 20132023, while information on smoking behaviours was obtained through a structured questionnaire developed for this study and distributed from May to August 2024

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