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This pharmacological effect of SCPP11 is associated with increased expression of the AMPK signaling pathway

Hamanaka, R

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Elemento, O., Leslie, C., Lundin, J

The direction of correlation between in vitro and in vivo findings appears broadly consistent across the body of evidence reviewed here: smaller PET NPs tend to have lower thresholds for biological effects, higher reactivity, more efficient biodistribution, and mechanisms of action more often driven by oxidative or genotoxic stress