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The conformational shift between the receptor in active and inactive states is therefore predicted to affect GLP-1R-cholesterol interactions, thereby leading to distinct active versus inactive cholesterol binding sites

Trial data from STEP 1 and SURMOUNT-1 show lean mass losses that can be functionally devastating in an already vulnerable population

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Over about two years, GLP-1 use was tied to a 41% lower rate of obesity-related cancers overall, and endometrial cancer, one of the most weight-driven cancers there is, dropped by 58%

Participants receiving semaglutide had a significantly lower decline in eGFR than those in the placebo group, indicating semaglutides potential kidney function protection in people with pre-existing kidney impairment