At the cellular level, vitamin B12 is involved in DNA synthesis and neuroprotection, acting as a cofactor for enzymes critical to these processes, such as methionine synthase and methylmalonyl-CoA mutase (72, 73)
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Pre-existing phosphorylations in these targets could possibly enhance their ability to compete with the phosphorylated pseudo-substrate for CDK11 binding, thereby supporting their further phosphorylation (Supplementary Fig
P., Mulligan, K., Schambelan, M., Murphy, E
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