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Characterization of genetic variants of GIPR reveals a contribution of -arrestin to metabolic phenotypes

doi: 10.1056/NEJMoa2206286

The thyroid safety concern stems from preclinical research in rodents, where semaglutide caused dose-dependent and treatment-duration-dependent thyroid C-cell tumors, including medullary thyroid carcinoma (MTC)

However, it has been shown that GLP-1 secretion in response to mixed nutrient (carbohydrates, fats and proteins) intake is much higher than that secreted after glucose ingestion

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Consume caffeine only in the morning or early afternoon (before 2 PM)