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Risks and Cautions : There is a significant risk that increasing vascularization can inadvertently support tumor growth, particularly if there are pre-existing tumors or cancer risks 1

The growth is driven by expanding therapeutic applications beyond diabetes, such as obesity and cardiovascular diseases

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J Biol Chem 278 : 6470 Nishi Y et al

However, in late-stage cancers, the infiltration of cancer cells results in an immunosuppressive microenvironment within LNs, which will favor immune evasion and secondary metastases