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Commenters discussed the statutory requirement at section 1886(d)(4)(C)(i) of the Act to update the relative weights at least annually to reflect changes in treatment patterns, technology

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Because we had not received the final CPT code numbers from AMA for the new codes that would be effective January 1, 2026, in time for the publication of the CY 2026 OPPS/ASC proposed rule, we listed the new CPT codes with their respective placeholder codes in OPPS Addendum B and Addendum O

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Additionally, laboratories may evaluate multiple compounds within the same category to better understand formulation consistency, preparation considerations, and analytical performance