administration 58, 59, 60, 61 of Ang II produced dose-dependent decreases in total renal blood flow (RBF) and renal cortical blood flow (CBF), and increases in renal vascular resistance and renal cortical vascular resistance, which were blocked by AT 1 receptor antagonists
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However, their expression in various tissues, albeit in smaller quantities, accounts for the multi-systemic effects of GLP-1RAs
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