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-secretase-catalyzed cleavage produces soluble APP and C99, a membrane-bound fragment of APP [50]

doi: 10.1186/1471-2458-9-88 21 YounossiZM

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doi: 10.1016/j.anaerobe.2016.12.003 53 HigarzaS

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Baseline synaptic density determines responsiveness: individuals with pre-existing cognitive deficits show stronger dose-dependent effects than those with intact baseline connectivity