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Tirzepatide (GLP-1) reduces excessive calorie intake, while Berberine HCl accelerates fat metabolism by activating cellular energy pathways

As of October 2024, a handful of these products are in late-phase clinical trials, with active ingredients such as retatrutide, survodutide and ecnoglutide, and more than 18 other drug candidates are in earlier stages of development

And their results have been mixed

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