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Compared with older pharmacologic options, GLP-1 receptor agonists and newer incretin-based therapies generally offer greater average weight reduction, but they also raise specific issues related to gastrointestinal tolerability, long-term continuation, affordability, and access ( 6 Safety and practical prescribing considerations in KOA patients Safety considerations are particularly important when GLP-1 receptor agonists are considered for patients with obesity-related KOA, because this population often includes older adults, patients with multimorbidity, and individuals approaching elective arthroplasty

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Bridge (July 1, 2026-December 31, 2027): Medicare Part D enrollees can access GLP-1 medications for weight loss or weight maintenance for $50 per fill