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Additionally, we observed that Ex-4c stimulated GLP-1Rs and activated the protein kinase A (PKA)-dependent signaling pathway, which in turn closed putative adenosine triphosphate-sensitive K + (K ATP ) channels, leading to the depolarization of POMC neurons

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Citation: Sevencan B, Steenackers N, van Laar ADE, et al

Compared to other weight loss approaches , tirzepatide demonstrates meaningful reductions in blood pressure, triglycerides, and inflammatory markers associated with cardiovascular risk

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