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The treated group (n = 40) received two daily doses of 300 mg of ALA (600 mg/day) and the control group (n = 40) received two daily doses of placebo
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In many human cancer cells, the KEAP1-mediated regulation of NRF2 activity is abrogated, resulting in the persistent activation of NRF2
10.1016/j.nut.2004.04.003 Nutrition 48 KaurA.YousufH.Ramgobin-MarshallD.JainR.JainR
Integrating these datasets with circulating or tissue biomarkers such as 8-hydroxy-2-deoxyguanosine, lipid peroxidation products, or CYGB levels could guide patient selection and dosing for antioxidant therapy [147]