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Consistent with the potency gained from introducing the 6-carboxylic acid motif in the benzimidazole region, the cryo-EM structure showed that the carboxylic acid of PF-06883365 is making a productive interaction with an arginine residue at position 380 in the GLP-1R binding pocket

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This corresponds to the period when gastric emptying is slowest before physiologic adaptation begins

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We've seen it time and time again: brilliant research designs can be completely undermined by one seemingly small misstep in the lab