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Although Syn wild-type ( WT ) has a hydrophobic (NAC) core, it is shielded by long-range intramolecular interactions, rendering it inert. In contrast, Parkinsons disease (PD)-specific Syn variantsS129 phosphorylation and C-terminal truncationsaggregate and phase separate more rapidly, suggesting hydrophobic exposure

January 2019

However, on account of strict homeostatic regulation of plasma L-carnitine concentrations, higher doses of L-carnitine supplementation may not provide additional therapeutic benefits

Read more Cavallini G, Caracciolo S, et al